Abstract
Background Central neurocytoma (CN) is a rare intraventricular neuronal tumor that predominantly affects young adults and is frequently associated with obstructive hydrocephalus. Surgical resection remains the cornerstone of treatment, yet the optimal surgical corridor and predictors of long-term outcome remain debated. Objective To evaluate the efficacy, safety, functional outcomes, and oncological control of transcortical microsurgical resection for central neurocytoma at a single neurosurgical center. Methods A retrospective review was conducted of all patients undergoing transcortical resection of central neurocytoma between 2017 and 2025. Clinical presentation, radiological characteristics, surgical approach, extent of resection, cerebrospinal fluid (CSF) diversion, postoperative complications, functional outcomes, recurrence, and survival were analyzed. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier methods. Results Eleven patients were included (mean age 29.7 years). Preoperative hydrocephalus was present in 72.7%. Gross total resection was achieved in 72.7%, while 27.3% underwent subtotal resection. Temporary external ventricular drainage was required in 63.6%, and permanent ventriculoperitoneal shunting in 45.5%. Postoperative complications occurred in 36.4%, predominantly transient, with persistent neurological deficit in 9.1%. Median follow-up was 24 months (range 12–50). Tumor recurrence occurred in one patient (9.1%) at 18 months following subtotal resection. No recurrences were observed after gross total resection. Overall survival at last follow-up was 100%. Conclusion Transcortical microsurgical resection is a safe and effective approach for central neurocytoma when selected according to ventricular anatomy. Gross total resection provides excellent tumor control, while hydrocephalus remains a key determinant of postoperative CSF diversion. Functional outcomes are favorable, and adjuvant radiotherapy should be reserved for residual or atypical tumors.
Article Type
Original Study
Subject Area
Neurosurgery
IRB Number
HAH00095
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Kandil, Eslam Abozied
(2026)
"Transcortical approach for central neurocytoma: efficacy, safety, and functional outcome,"
Journal of Medicine in Scientific Research: Vol. 9:
Iss.
3, Article 5.
DOI: https://doi.org/10.59299/2537-0928.1523
