Early Clinical Outcomes of The Use of del Nido Versus Intermittent Warm Blood Cardioplegia After Isolated Coronary Artery Bypass Surgery

Authors

• Ahmed Abdalla Mohamed, National Heart Institute, Cardiac Surgery Dept.Follow
• Ahmed M Elshemy, National Heart Institute, Cardiac Surgery Dept
• Sherif M Elboghdady, National Heart Institute, Cardiac Surgery Dept
• Wael S Nekhila, National Heart Institute, Cardiac Surgery Dept.
• Ismail R Barrada, National Heart Institute, Cardiac Surgery Dept.

Abstract

Background While the best approach to protecting the heart during surgery varies based on the specific operation and the surgeon's preferences, del Nido cardioplegia, initially successful in children, is gaining traction as an alternative to the traditional blood cardioplegia in adult cardiac procedures. Aim This investigation comparatively analysed the early postoperative consequences in adult patients undergoing isolated coronary artery bypass grafting, contrasting the application of del Nido cardioplegia with conventional warm blood cardioplegia techniques. Methods Randomised controlled clinical research was conducted to compare the efficacy of antegrade del Nido (DNC) and intermittent warm blood cardioplegia (IWBC) in safeguarding myocardial function during CABG. One hundred adult patients scheduled for isolated CABG were prospectively enrolled and randomly assigned to two equal cohorts. Preoperative, intraoperative, and postoperative data were collected and analysed to assess the impact of cardioplegia on various outcome measures. Results The study found no significant differences in demography, baseline characteristics, intraoperative variables (e.g., cross-clamp time, total bypass time), and most postoperative outcomes (e.g., laboratory parameters, ventilation time, ICU stay, echocardiographic parameters, complications). However, significant differences were observed in the need for using haemofilters, dysrhythmias, and electrical cardioversion. Conclusion This study concluded comparable effectiveness and protection in safeguarding myocardial function for both techniques. While differences were observed in certain intraoperative outcomes, both strategies effectively preserved myocardial function and facilitated postoperative recovery. Home message DNC and IWBC effectively protect the myocardium during CABG. Differences were seen in hemofiltration, dysrhythmias, and electrical cardioversion.

Article Type

Original Study

Subject Area

Cardiothoracic Surgery

IRB Number

IHC00117

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Recommended Citation

Mohamed, Ahmed Abdalla; Elshemy, Ahmed M; Elboghdady, Sherif M; Nekhila, Wael S; and Barrada, Ismail R (2026) "Early Clinical Outcomes of The Use of del Nido Versus Intermittent Warm Blood Cardioplegia After Isolated Coronary Artery Bypass Surgery," Journal of Medicine in Scientific Research: Vol. 9: Iss. 3, Article 13.
DOI: https://doi.org/10.59299/2537-0928.1525