Association of Arterial Partial Oxygen Pressure with Mortality in Critically Ill Patients with Sepsis: An Observational Prospective Cohort Study

Authors

• Talal Ibrahim mostafa Hagag, MD of critical Care Medicine lecturer of critical care medicine Shebin Elkom Teaching Hospital, General Organization for Teaching Hospitals and Institutes.Follow
• Salwa M.A. Dahesh, Prof. of Public Health Sciences (Parasitology and Medical Entomology) Research Institute of Medical Entomology, GOTHI, Cairo, Egypt

Abstract

Background Up till now, the best oxygenation plan in sepsis is a moot point. Although both hypoxemia and hyperoxemia have been linked to negative outcomes, it is unclear whether the arterial oxygen tension (PaO₂) contributes to mortality on its own. The present study aimed to study the association between the arterial partial oxygen pressure and the mortality among critically ill patients with sepsis. Methods A prospective observational study was carried out, including 120 critically ill patients with sepsis. The patients were classified according to arterial partial oxygen pressure into two groups: the PaO₂ >80 mmHg group, which included 61 patients, and the 60–80 mmHg group, which included 59 patients. The two groups were compared according to their demographic data, Laboratory findings, oxygenation variables, comorbidities, and SOFA scores. The included patients were subdivided into two groups based on 28-day mortality and compared with the mortality cases. A logistic regression was established for estimating associated factors to the mortality during 28 days. Results The results revealed that there was no difference between PaO2 groups according to gender, age, baseline SOFA scores, lactate, vasopressor use, or comorbidities, but the >80 mmHg group had significantly higher white blood cell counts. The death rate was 37.5%. ICU stays were longer, and SOFA scores were higher for non-survivors. The logistic regression revealed that SOFA was the only independent predictor associated significantly with 28-day-mortality. Conclusion: A conservative oxygen strategy was supported by the fact that the SOFA score was the strongest prognostic factor associated with 28-day mortality, while neither PaO₂ nor PaO₂ or age was associated.

Article Type

Original Study

Subject Area

Critical Care Medicine

IRB Number

HSH00091

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Recommended Citation

Hagag, Talal Ibrahim mostafa and Dahesh, Salwa M.A. (2026) "Association of Arterial Partial Oxygen Pressure with Mortality in Critically Ill Patients with Sepsis: An Observational Prospective Cohort Study," Journal of Medicine in Scientific Research: Vol. 9: Iss. 3, Article 10.
DOI: https://doi.org/10.59299/2537-0928.1533