Markers of Tissue Hypoperfusion and Response to Vasopressors in Patients with Septic Shock

Authors

Islam M. El-Desoky, Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, 32511, EgyptFollow
Ahmed A. Abdelaziz, Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt
Hossam A. Galbt, Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt.
Ahmed S. Abdelgawad, Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt.
Ola S. Mohamed, Critical Care Medicine, Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt

Abstract

Background Patients in the early stage of septic shock require individualized fluid resuscitation and early administration of vasopressors to ensure tissue perfusion. We aimed to assess the performance of tissue perfusion markers in patients with septic shock and assessing its role in predicting the response to vasopressors. Methods This observational study was included 90 patients with septic shock within the first 24 hours of admission to the intensive care. Arterial (a) and central venous (cv) blood samples were obtained before beginning vasopressors (T0), and then at 12 and 24 hours after the initial sampling (T12, 24) for analysis of oxygen (O2), carbon dioxide (CO2) and other laboratory measures. Results In our cohort; 51 (56.7%) resolved and 39 (43.3%) deceased. The PaO2, PaCO2 and SaO2 showed significantly lower values in the deceased than resolved patients after 24 hours (P

Article Type

Original Study

Subject Area

Critical Care Medicine

IRB Number

6/2023 ANET 2-4

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Recommended Citation

El-Desoky, Islam M.; Abdelaziz, Ahmed A.; Galbt, Hossam A.; Abdelgawad, Ahmed S.; and Mohamed, Ola S. (2025) "Markers of Tissue Hypoperfusion and Response to Vasopressors in Patients with Septic Shock," Journal of Medicine in Scientific Research: Vol. 8: Iss. 4, Article 4.
DOI: https://doi.org/10.59299/2537-0928.1464