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Abstract

The effectiveness of peppermint and eucalyptus oils was examined in the current study to the rat fleas (Xenopsylla cheopis). The constituents of each oil were identified by GC-MS. The LC50 and LC90 for each essential oil were calculated after 1 and 24 hours exposure. The effect of peppermint and eucalyptus oils on some vital process in albino rat treated with 1/10 and 1/20 of LD50 were studied for the ALT, AST, Urea and creatinine levels. TNF-α and IL-6 levels also were studied. Data indicated that peppermint essential oil had more efficacy than that of eucalyptus for 1 and 24 hours exposure. The LC50 were (8.25% and 1.8%) for peppermint and (10.5 % and 2.37%) for eucalyptus to 1 hour and 24 hours, respectively. While its LC90 were (16.7% and 3.7 %) for peppermint and (17.9% and 5.3%) for eucalyptus to 1hour and 24 hours, respectively. Data showed that the administration of peppermint and eucalyptus essential oils had no significant effect in serum urea and serum creatinine to all treated group compared to control. Administration of 1/10 LD50 and 1/20 LD50 for peppermint essential oil showed no change for the serum ALT and AST but showed significant increase for them serum to 1/10 LD50 eucalyptus oil, while 1/20 LD50 eucalyptus showed no significant changes for the serum ALT and AST. Data also showed that the administration of 1/10 LD50 for both essential oils increased IL-6 and TNF-α level but their 1/20 LD50 not change IL-6 and TNF-α levels compared to control group

Article Type

Original Study

Subject Area

Medical and Immunological Biology

IRB Number

IME00068

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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