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Abstract

Introduction: This study, Element Type, reflects the prevalence of and clinical significance of aseptic pyuria among CKD patients in Egypt, addressing the vital knowledge gap that exists in understanding what implications this condition presents to the patient. More than 10% of the world's population suffers from chronic kidney disease that is characterized by progressive loss of renal function and requires monitoring of various clinical parameters, including pyuria and white blood cells present in urine. Aseptic pyuria is commonly misunderstood as a UTI and thereby mistreated with unnecessary antibiotic courses due to the presence of white blood cells with no bacterial infection. In this way, misdiagnosis enhances antibiotic resistance and complicates the management of CKD patients. Patients and Methods: This will be a cross-sectional study of 90 stable CKD patients, divided into three groups of patients according to their eGFR: Stage 3 (30-59 ml/min/1.73 m²), Stage 4 (15-29 ml/min/1.73 m²), and Stage 5 (< 15 ml/min/1.73 m², on hemodialysis). Data collection was done through the analysis of urine samples and from patient medical records, focusing on the relationship between aseptic pyuria and renal function and investigating its possible role as a biomarker of inflammation and CKD progression. Results indicate that the prevalence of aseptic pyuria significantly increased from 40% in Stage 3 to 73.3% in Stage 5 CKD. Aseptic pyuria was associated with increased levels of urea, creatinine, and CRP, with decreased values of eGFR. This may indicate that aseptic pyuria is an indicative signal of the underlying inflammation and kidney injury in CKD progression. Conclusion: The study thus calls for further studies to explain the cause and long-term impact of aseptic pyuria in patients with CKD. By better understanding the nature of this condition, healthcare professionals can improve diagnostic accuracy, decrease improper antibiotic use, and optimize patient outcomes related to CKD.

Article Type

Original Study

Subject Area

Nephrology

IRB Number

IUN00048

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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