Relationship Between Thyroid-Stimulating Hormone (TSH) Levels And The Presence of Non-Alcoholic Fatty Liver Disease (NAFLD) Among asymptomatic individuals

Mohamed Ramzy Alawy, Fellow of Internal MedicineShebin El kom Teaching HospitalFollow
Shimaa M W Kalama, Fellow of General Surgery Shebin El kom Teaching Hospital
Rania T H Gebba, MD of Clinical Pathology Shebin El kom Teaching Hospital
Samah Mohammed Abdelmonem Abu sholaa, Msc, FEBR in diagnostic radiology Shebin El kom Teaching Hospital
Asmaa M Soliman, Fellow of Biochemistry National Nutrition Institute

Article Type

Original Study

Subject Area

Internal Medicine

Abstract

Background: Thyroid gland and its hormones have a crucial effect in body weight regulation, metabolism of lipid, and insulin sensitivity, which all of them play an important and significant effect in the process of non-alcoholic fatty liver disease (NAFLD) development. Aim: This study aimed to evaluate the potential risk of occurrence of metabolic syndrome in euthyroid persons with NAFLD . Subjects and Methods: - This cross-sectional study was carried out on outpatient cases in the Department of Internal Medicine at Shebin El-Kom Teaching Hospital. Conducted between February 2024 and August 2024, our study included 96 participants recruited from outpatient clinic. All participants were divided into 2 groups: - 1st group included 48 subjects without NAFLD (control group) & 48 persons diagnosed with NAFLD (cases group). Participants in this study underwent clinical evaluation, physical assessment, and laboratory tests. Multivariate logistic regression analysis and descriptive statistics were used to evaluate different factors associated with NAFLD and thyroid function. Results: levels of TSH were significantly higher in the (cases) NAFLD group compared to (control) non NAFLD group (p = 0.001). “Pos/t-hoc analysis showed a significant difference in levels of TSH between the two groups (p = 0.001).. Additionally, NAFLD group showed significant elevations in different metabolic markers as triglycerides, total cholesterol, LDL cholesterol, body mass index ( BMI), random blood sugar and glycosylated Hb. When compared to age-matched controls, the NAFLD group also showed higher systolic and diastolic blood pressure, FIB-4 (fibrosis index), and FLI (fatty liver index).

IRB Number

HSH00074

Keywords

Non-Alcoholic Fatty Liver Disease (NAFLD)- thyroid stimulating hormone (TSH)- - Fibrosis score (FIB4) -- Fatty liver index (FLI)

Recommended Citation

Alawy, Mohamed Ramzy; Kalama, Shimaa M W; Gebba, Rania T H; sholaa, Samah Mohammed Abdelmonem Abu; and Soliman, Asmaa M (2024) "Relationship Between Thyroid-Stimulating Hormone (TSH) Levels And The Presence of Non-Alcoholic Fatty Liver Disease (NAFLD) Among asymptomatic individuals," Journal of Medicine in Scientific Research: Vol. 8: Iss. 2, Article 1.
DOI: https://doi.org/10.59299/2537-0928.1426