Spirometry Reference Equations: A Comparative Cross-Sectional Study In Egyptian Population Sample

Mohamed Gaber El-Shiekh, Chest department, Mataria teaching hospital, General organization for teaching hospitals and institutes, Cairo, EgyptFollow

Article Type

Original Study

Subject Area

Thoracic and Chest Diseases

Abstract

Context:

Global lung initiative-2012 (GLI-2012) was published and endorsed by many international societies as the standard reference for spirometry interpretation. European coal and steel community (ECSC) equation updated in 1993 by the European respiratory society (ERS) is still widely used in Egypt as a reference.

Aims:

Investigating the difference between GLI-2012 and ECSC-ERS93 reference values.

Settings and Design:

Retrospective cross-sectional study in Mataria teaching hospital.

Methods and Material:

Spirometry tests (fulfilling the latest ERS acceptability criteria) for Egyptian subjects, from January 2022 to July 2024 were included. GLI-2012 and ECSC-ERS93 values of predicted and lower limit of normal (LLN) for Forced vital capacity (FVC), Forced expiratory volume in first second (FEV₁), and FEV₁/FVC ratio LLN were retrieved and compared.

Statistical analysis used:

Wilcoxon signed rank test for comparison, and agreement checked using Bland-Altman plot.

Results:

Five hundred thirty five subjects were included in the final analysis (56% were males), median age 43 years (34-55), median body mass index (BMI) 29.41(25.39-34.75), Wilcoxon test revealed statistically significant difference between ECSC-ERS93 and GLI-2102 reference values for predicted and LLN of FVC, FEV₁, and FEV/FVC ratio LLN, more over Bland-Altman analysis; revealed that ECSC-ERS93 underestimated FEV₁/FVC LLN, predicted FVC, FVC LLN, predicted FEV₁, FEV₁ LLN by an average of -0.524%, -304 mL, -294 mL, -163 mL, -178 mL, respectively.

Conclusions:

GLI-2012 equation is yielding higher values compared to ECSC-ERS93 predictive equation; shifting to GLI-2012 is strongly warranted in Egypt with its expected impact on detection and diagnosis of various respiratory diseases.

IRB Number

HM000176

Keywords

GLI-2012, ECSC-ERS93, reference equations, spirometry

Recommended Citation

El-Shiekh, Mohamed Gaber (2024) "Spirometry Reference Equations: A Comparative Cross-Sectional Study In Egyptian Population Sample," Journal of Medicine in Scientific Research: Vol. 8: Iss. 1, Article 5.
DOI: https://doi.org/10.59299/2537-0928.1423