Article Type
Original Study
Subject Area
Obstetrics and Gynecology
Abstract
Background: This study seeks to question the customary utilization of HCG in straightforward letrozole induction methods, proposing its restricted requirement in particular instances, perhaps diminishing expenses and anxiety for infertile couples.
Material and Methods: This is a prospective cohort study was done at the assisted reproductive unit in Ahmed Maher teaching hospital in Cairo. The study includes 132 infertile women aged 18 to 35 with PCOS, free from other medical disorders and not taking conflicting medications.
Prerequisites involve normal hysterosalpingography and semen analysis. Participants were evenly divided into two groups: the first receiving letrozole exclusively for ovulation induction, and the second receiving letrozole with HCG when suspected ovulation maturity occurred.
Following a 2-week period, both groups underwent a pregnancy test, and individuals with positive results received a transvaginal ultrasound one week later for clinical pregnancy confirmation.
Results: The results of the pregnancy tests were the same in both groups, with 15 women (22.7%) testing positive. The P-value was 1. In terms of clinical pregnancy, the group that received only Letrozole had 14 pregnancies (21.2%), which was somewhat higher than the group that received Letrozole and HCG, which had 13 pregnancies (19.7%). However, this difference was not statistically significant (p-value = 0.829).
Conclusion: The study indicates that the letrozole-only regimen is slightly more effective than the letrozole+HCG strategy for fertility treatment in women with polycystic ovarian syndrome, particularly in terms of achieving clinical pregnancy. The results additionally suggest that HCG should only be used in situations where intrauterine insemination is necessary or for persons who have been diagnosed with luteinized unruptured follicle syndrome.
IRB Number
HAM00170
Keywords
Letrozole, PCO, Induction of ovulation, Infertility.
Recommended Citation
Kassab, Ahmed A.; Salman, Ahmed M.; Khattab, Heba M.; Khayal, Ali; Abdelmordy, Sherif; and Elazab, Mohammed I.
(2024)
"The effect of using letrozole alone protocol versus using letrozole and HCG protocol on induction of ovulation in polycystic ovarian syndrome patients: A prospective cohort study,"
Journal of Medicine in Scientific Research: Vol. 8:
Iss.
1, Article 3.
DOI: https://doi.org/10.59299/2537-0928.1418
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