•  
  •  
 

Article Type

Original Study

Subject Area

Internal Medicine

Abstract

Background: Liver cirrhosis disease is regarded as a major global health concern and is linked to several insults. One of its most frequent injuries, portal hypertensive gastropathy (PHG), can cause bleeding in the gastrointestinal tract. With a global prevalence of 50%, Helicobacter pylori (H. pylori) is regarded as one of the most prevalent harmful organisms. As of right moment, it is unclear how H. pylori infection and PHG are related.

Objective: To find out if PHG severity in cirrhotic cases is associated with H. pylori infection, and to explore the association between H. pylori infection and PHG.

Methodology: In a retrospective research, individuals with upper endoscopy-diagnosed cirrhosis were divided into two groups based on whether PHG was present or absent. Group 1 consisted of 13 cirrhotic individuals who were age and sex matched and did not have PHG. Group 2 consisted of 47 cirrhotic patients with varying PHG grades who were age and sex matched. PHG and an H. pylori infection were found by endoscopic evaluation.

Results: According to histology, 30 patients (about 50%) had H. pylori infection. Patients with PHG who were cirrhotic had a higher prevalence of H. pylori infection (86.7%) compared to those without PHG (13.3%) (P=0.038). Those with PHG had a higher prevalence of H. pylori infection than those without PHG (p-value = 0.038).

Conclusion: The results of this study indicate that in cirrhosis patients, H. pylori infection and PHG are significantly correlated. Compared to patients without PHG, those with PHG experienced a significantly higher prevalence of H. pylori infection.

IRB Number

HAM00189

Keywords

H. pylori; Portal Hypertensive Gastropathy

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Download

Share

COinS