Association Between Urolithiasis and Non-Alcoholic Fatty Liver Disease ; A Comprehensive Study In National Institute of Urology and Nephrology

Jehan Ibrahim M. AlTohamy, Lecturer of Radiology, National Institute of Urology and Nephrology (NIUN) And Armed Forces Collage of Medicine (AFCM)Follow
Basma Aref ElTaweel, Lecturer of nephrology, National Institute of Urology and Nephrology
Ahmed Mostafa ElGamal, Lecturer of urology, National Institute of Urology and Nephrology
Salwa Mohammed Ahmed Dahesh, Prof. of Public Health, Research Institute of Medical Entomology
Ghadir Mohamed Elsawy, Lecture of clinical pathology, National Institute of Urology and Nephrology

Article Type

Original Study

Subject Area

Diagnostic and Interventional Radiology

Abstract

Background: Numerous studies have documented an important association between non-alcoholic fatty liver disease (NAFLD) and urolithiasis. NAFLD is described as 5% fat or more of the liver contents in other liver diseases absence including those related to alcohol consumption, chronic viral hepatitis, other chronic liver diseases as autoimmune hepatitis, and drug-induced hepatic diseases (1). Liver tru-cut biopsy is considered the gold standard yet invasive NAFLD diagnostic technique and carries potential complications (2). On the other hand, Computed Tomography (CT) is considered a non-invasive convenient tool that allows for measurable assessment of NAFLD allowing for quantitative diagnosis. Consequently, CT has proven to be a valuable technique for patient monitoring and follow-up (3). Currently, there is a research gap regarding exploring diagnostic or therapeutic approaches for both fatty liver and urolithiasis, possibly due to the unknown association between these two conditions (4). Aim and objectives: This study aims to investigate the potential formation of renal lithiasis (urinary stone formation) in patients with fatty liver disease. The researchers aim to identify shared metabolic as well as epidemiological factors that could potentially decrease the occurrence and complications of both conditions. Material & methods: Retrospectively collected data proved by the institutional board.

All the patients above 18 years old who visited our institute (National Institute Of Urology And Nephrology) and performed CT on urinary tract without contrast among Mars 2023 & October 2023, utilizing Aquilion 64 multi-slice helical acquisition system, Toshiba Medical Systems). Results: Out of the 490 cases, 290 were classified as healthy or had other pathologies other than fatty liver or renal stone disease, accounting for 60% of the total. The renal stone disease group was 100 patients (37 men, 63 women) and fatty liver was 52 patients. 40 of which were associated with urolithiasis (76.9%) (p < 0.05) while only 12 were enrolled in the non-urolithiasis group ( 23.1%) (p < 0.05).

IRB Number

IUN00043

Keywords

Non-Alcoholic Fatty Liver Disease; NAFLD; NASH; Fatty Liver; Urolithiasis; CT

Recommended Citation

AlTohamy, Jehan Ibrahim M.; ElTaweel, Basma Aref; ElGamal, Ahmed Mostafa; Dahesh, Salwa Mohammed Ahmed; and Elsawy, Ghadir Mohamed (2024) "Association Between Urolithiasis and Non-Alcoholic Fatty Liver Disease ; A Comprehensive Study In National Institute of Urology and Nephrology," Journal of Medicine in Scientific Research: Vol. 8: Iss. 1, Article 10.
DOI: https://doi.org/10.59299/2537-0928.1424