Role of Progesterone and Inhibin A in Predicting the Adverse Outcome of Pregnancy

Ahmed Hassan Khedr, Associate Professor of Obstetrics & Gynecology, Faculty of Medicine, Helwan University, Egypt
Amany Seif Mohammed Soliman, M.B.B.CH, M. Sc., Faculty of Medicine, Cairo University, Egypt.
Yasmine M. Amrousy, Associate Professor of Clinical and Chemical Pathology, Faculty of Medicine, Helwan University, EgyptFollow
Shaimaa Elsayed Belal, Associate Professor of Obstetrics & Gynecology, Faculty of Medicine, Helwan University, Egypt

Article Type

Original Study

Subject Area

Obstetrics and Gynecology

Abstract

Background: The prediction of future miscarriages in patients who have had a first-trimester abortion can be improved by measuring levels of inhibin A and progesterone. Pregnancy outcomes can be improved by using this important information to direct clinical treatment and care Objective. Progesterone and Inhibin A during the first trimester can be used to quickly and precisely detect pregnancy outcomes, improving prenatal services. Methods: A total of 180 women from Badr City Hospital participated in the study, split up into two groups: group b contained ninety women who had undergone a first-trimester abortion, and group a comprised ninety well-being expectant mothers. The cases was carefully evaluated by comprehensive medical history, cervical-pelvic examinations, and transvaginal ultrasound. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of progesterone and inhibin A in blood samples. The goal of the study was to compare the two groups' hormone levels. Results: The findings of the study indicate that low progesterone levels, high diastolic blood pressure, previous abortions, and primigravida may independently contribute to the risk of abortion with odds ratios (95% confidence intervals) , 0.895 (0.850-0.943), 1.123 (1.018-1.240), 26.857 (8.769-82.250) respectively, with associated p-values of

IRB Number

1-2022

Keywords

progesterone, early marker, previous abortion, inhibin A.

Recommended Citation

Khedr, Ahmed Hassan; Soliman, Amany Seif Mohammed; Amrousy, Yasmine M.; and Belal, Shaimaa Elsayed (2024) "Role of Progesterone and Inhibin A in Predicting the Adverse Outcome of Pregnancy," Journal of Medicine in Scientific Research: Vol. 7: Iss. 2, Article 9.
DOI: https://doi.org/10.59299/2537-0928.1072