An analytical study of the risk factors affecting the platelet aggregation in patients with sepsis

Vishnu Priya, Departments of Medicine , Vardhman Mahavir Medical College & Safdar Jang Hospital, New Delhi, India
Jitender M. Khunger, Department of Haematology, Vardhman Mahavir Medical College & Safdar Jang Hospital, New Delhi, IndiaFollow
Anupma Arora, Departments of Haematology, Vardhman Mahavir Medical College & Safdar Jang Hospital, New Delhi, India

Article Type

Original Study

Subject Area

Internal Medicine

Abstract

Objectives (a) To determine the correlation of platelet count and aggregation with sepsis severity and (b) to find the risk factors affecting the platelet aggregation in sepsis. Patients and methods The present observational cross-sectional study was conducted on 30 patients of sepsis over a period of 18 months. All patients underwent complete blood counts, and platelet aggregation to ADP. Pearson correlation coefficient was used to assess the association of Sequential Organ Failure Assessment (SOFA) score and aggregation to ADP and platelet. Linear regression was done to determine the risk factors affecting platelet aggregation in sepsis. A P value of less than 0.05 was considered statistically significant. Results The age of the patients ranged from 19 to 70 years with 12 females and 18 males. The mean (SD) SOFA was 7.73 (3.92). Thrombocytopenia (/μl) was observed in 17 (56.6%) patients. Platelet count was statistically significantly negatively correlated with severity of sepsis as assessed by SOFA scoring system (r=0.492, P=0.006). Platelet aggregation was decreased, that is, less than 65%, in 15 (50%) patients, and was normal in the rest of 15 (50%) patients. No statistically significant correlation was observed between ADP-induced platelet-aggregation abnormality and SOFA score in patients with sepsis (r=0.0354, P=0.55). Conclusion Since most of the cases in the study had mild sepsis, it can be concluded that alteration in the platelet aggregation is more with the severe sepsis and thrombocytopenia is an initial finding that begins even in the mild cases of sepsis and increases proportionately with the severity of sepsis.

Keywords

platelet aggregation, sepsis, Sequential Organ Failure Assessment score

Recommended Citation

Priya, Vishnu; Khunger, Jitender M.; and Arora, Anupma (2023) "An analytical study of the risk factors affecting the platelet aggregation in patients with sepsis," Journal of Medicine in Scientific Research: Vol. 6: Iss. 4, Article 4.
DOI: https://doi.org/10.59299/2537-0928.1011