Comparative study between intravenous anesthesia (propofol) and inhalational anesthesia (sevoflurane) on the cytokine’s response to abdominal operation

Ashraf A.H. Mahmoud Soliman, Departments of Anesthesia, National Heart Institute, GizaFollow
Maisa M. Abdel Khalik, Department of Anesthesia, Al-Mataria Teaching Hospital
Wael A.E. El Hakeem, Departments of Critical Care, National Heart Institute, Giza
Raghad S. Abdellatif, Department of Clinical Pathology, National Hepatology and Tropical Medicine Research Institute, Egypt

Article Type

Original Study

Subject Area

Anaesthesiology

Abstract

Introduction These days, the need for more information and familiarity with the inflammatory response to different anesthetic drugs increase. Not only some patients suffering from immune reactions against some anesthetic drugs, but all surgical patients are liable to decrease in immunity postoperatively. This may increase the postoperative morbidity and mortality, affects healing, and spread of tumors postoperatively. This decrease in immunity is due to surgery trauma causing imbalance in cytokine response. Patients and methods This article was written on 40 patients, and patients were randomly classified into four equal classes. Class A: inhalational anesthesia on major operation. Class B: intravenous anesthesia on major operation. Class C: inhalational anesthesia on minor operation. Class D: intravenous anesthesia on minor operation. Results The authors found that proinflammatory cytokine [interleukin (IL)-6] levels increase postoperatively in all classes but with higher levels in inhalational anesthesia more than intravenous anesthesia and in major operation than in minor operation. Anti-inflammatory cytokine (IL-10) increases slightly in intravenous anesthesia more in major operation and was higher in inhalational anesthesia, especially after 24 h postoperatively, more in major operation. We also noticed a correlation between cortisol level with IL-6 levels, this means an increase more in major operation than in minor operation and with higher levels in inhalational anesthesia than intravenous anesthesia, which shows slight increase in cortisol level. Conclusion Inhalational anesthesia had the highest effect to induce inflammatory cytokine response to operations than the intravenous anesthesia, whether on major or minor operations

Recommended Citation

Soliman, Ashraf A.H. Mahmoud; Khalik, Maisa M. Abdel; El Hakeem, Wael A.E.; and Abdellatif, Raghad S. (2023) "Comparative study between intravenous anesthesia (propofol) and inhalational anesthesia (sevoflurane) on the cytokine’s response to abdominal operation," Journal of Medicine in Scientific Research: Vol. 6: Iss. 2, Article 5.
DOI: https://doi.org/10.59299/2537-0928.1020