Effect of Empagliflozin Metformin with Clomiphene Citrate versus Metformin with Clomiphene Citrate on cases of Polycystic Ovary Syndrome

Diaa Shams Eldin El Gohary, Obstetrics and Gynecology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.Follow
Mohammed Mohammed Ismail, Obstetrics and Gynecology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Ahmed Mahmoud El khayat, Obstetrics and Gynecology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Sherin Barakat Elbohoty, Obstetrics and Gynecology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Article Type

Original Study

Subject Area

Obstetrics and Gynecology

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences. Aim and objectives: In this research, we aimed to assess the impact of Empagliflozin Metformin with Clomiphene Citrate versus Metformin with Clomiphene Citrate on weight reduction and its impact on folliculometry and ovarian volume in cases of Polycyctic Ovary Syndrome. Subjects and Methods: This was a randomized clinical trial; in which 150 Patients were being randomly assigned into two equal groups; Group A: 75 cases received empagliflozin metformin 12.5/500 mg Continously once daily plus clomiphene citrate 50 mg twice daily for 3 cycles cycles from day 2 of the natural or the withdrawal cycle for 5 days. Group B: 75 cases received metformin 500 mg continously once daily plus clomiphene citrate 50 mg twice daily for 3 cycles from day 2 of the natural or the withdrawal cycle for 5 days. Results: there was a significant variation between the two studied groups regarding BMI hip circumference ovarian characteristics (ovarian volume and AFC), FBG, fasting insulin and ovulation rate. Conclusion: Empagliflozin metformin with clomiphene citrate treatment had beneficial effects on anthropometric parameters (BMI and hip circumference), ovarian characteristics (ovarian volume and AFC), FBG, fasting insulin and ovulation rate in women with PCOS compared to metformin with clomiphene citrate, but no statistically significant variations were seen in number of dominant follicles, pregnancy rate and positive pregnancy.

IRB Number

34763/6/21

Keywords

PCO; metformin; ovulation; metabolic; empagliflozin; anthropometric parameters.

Recommended Citation

El Gohary, Diaa Shams Eldin; Ismail, Mohammed Mohammed; El khayat, Ahmed Mahmoud; and Elbohoty, Sherin Barakat (2023) "Effect of Empagliflozin Metformin with Clomiphene Citrate versus Metformin with Clomiphene Citrate on cases of Polycystic Ovary Syndrome," Journal of Medicine in Scientific Research: Vol. 6: Iss. 2, Article 3.
DOI: https://doi.org/10.59299/2537-0928.1025