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Article Type

Original Study

Abstract

Background The objective of this study was to determine the favorable effects of multimineral-vitamin D supplementation on pregnancy outcomes among women at risk for preeclampsia. Patients and methods This randomized double-blind controlled clinical trial was conducted among 46 women at risk for preeclampsia at 27 weeks of gestation, with positive roll-over test. Pregnant women were randomly assigned to receive either the multimineral-vitamin D supplements (n = 23) or the placebo (n = 23) for 9 weeks. Multimineral-vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU vitamin D3. Fasting blood samples were taken at baseline and after 9-week intervention to measure related factors. Newborns' outcomes were determined. Results Although no significant difference was seen in newborns' weight and head circumference between the two groups, mean newborns' length (51.3 ± 1.7 vs. 50.3 ± 1.2 cm, P = 0.03) was significantly higher in multimineral-vitamin D group than that in the placebo group. Compared to the placebo, consumption of multimineral-vitamin D supplements resulted in increased levels of serum calcium (+0.19 vs. −0.08 mg/dl, P = 0.03), magnesium (+0.15 vs. −0.08 mg/dl, P = 0.03), zinc (+8.25 vs. −21.38 mg/dl, P = 0.001), and vitamin D (+3.79 vs. −1.37 ng/ml, P = 0.01). In addition, taking multimineral-vitamin D supplements favorably influenced systolic blood pressure (−1.08 vs. 6.08 mmHg, P = 0.001) and diastolic blood pressure (DBP) (−0.44 vs. 3.05 mmHg, P = 0.02). Conclusions Multimineral-vitamin D supplementation for 9 weeks in pregnant women at risk for preeclampsia resulted in increased newborns' length; increased circulating levels of maternal serum calcium, magnesium, zinc, and vitamin D; and led to decreased maternal systolic blood pressure and diastolic blood pressure.

Keywords

Multimineral-vitamin D supplementation, preeclampsia, pregnancy outcomes

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