Article Type
Article
Subject Area
Clinical and Chemical Pathology
Abstract
Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disorder triggered by both environmental and genetic risk factors. Although some studies have reported that single-nucleotide polymorphisms of vitamin D receptor (VDR) gene play a role in T1DM susceptibility, their associations are inconclusive and remain controversial in different ethnic groups. This case–control study aimed to evaluate the association between VDR (BsmI-rs1544410 and FokI-rs2228570) single-nucleotide polymorphisms and T1DM in Egyptian children. A total of 100 participants, 50 children with T1DM (cases) and 50 nondiabetic, age-matched and sex-matched patients (controls), were enrolled in the study in which BsmI-rs1544410 and FokI-rs2228570 variants were genotyped using TaqMan real-time PCR technology. Results VDR gene (BsmI-rs1544410 and FokI-rs2228570) variants are not associated with T1DM in Egyptian children. Conclusions VDR (BsmI-rs1544410 and FokI-rs2228570) variants did not differ significantly between T1DM cases and nondiabetic controls among Egyptian children.
Keywords
BsmI-rs1544410 and FokI-rs2228570, type 1 diabetes mellitus, vitamin D receptor gene
Recommended Citation
Mohyi, Abeer M.; El-Abd, Dina M.; Rashed, Eman A.; Omar, Ghada A.; and A. AbdulLatif, Mona M.
(2022)
"Association between vitamin D receptor gene (BsmI-rs1544410 and FokI-rs2228570) polymorphisms and type 1 diabetes mellitus in Egyptian children,"
Journal of Medicine in Scientific Research: Vol. 5:
Iss.
2, Article 4.
DOI: https://doi.org/10.4103/jmisr.jmisr_4_22
