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Article Type

Article

Subject Area

Chest

Abstract

Introduction There are insignificant observations and few research studies that indicate the action of Helicobacter pylori in the induction of extra-gastrointestinal tract diseases, which include autoimmune, skin, and vascular diseases, and also some pulmonary diseases. Moreover, it has been documented that the incidence of chronic bronchitis may be elevated in patients who experienced H. pylori infection. Aim To assess infection with H. pylori in patients with chronic obstructive pulmonary disease (COPD) and in control persons and also to determine the association between serology level of H. pylori and spirometry parameters in patients experiencing COPD. Results A total of 100 individuals experiencing COPD and 100 age-matched and sex-matched controls were included. The mean age in patients with COPD was 63.3 ± 8.4, whereas in controls was 60.8 ± 8.8. All participants of the current study underwent ELISA and immunoglobulin G (IgG) serology examination for H. pylori. The percentage of anti-H. pylori IgG seropositivity in patients with COPD was 78%, whereas in controls was 55% (P < 0.001). Moreover, patients experiencing COPD had a statistically highly significant elevated mean serum concentration of anti-H. pylori IgG antibodies. The mean level of anti-H. pylori IgG in patients with COPD was 120.5 ± 22.5 U/ml, whereas in the control group was 62.3 ± 11.6 U/ml (P<0.001). There was a highly significant reduction in forced expiratory volume in 1 s (FEV1) in H. pylori-positive patients with COPD than in H. pylori-negative patients with COPD. Mean FEV1 in patients with H. pylori-positive COPD was 49.56 ± 12.16, whereas in patients with H. pylori-negative COPD was 88.09 ± 2.24 (P < 0.001). There was also a statistically highly significant negative correlation between FEV1 value and serum concentration of anti-H. pylori IgG antibodies (P < 0.001). Conclusion The parameters indicate that there is a correlation between H. pylori infection and COPD.

Keywords

Chronic obstructive pulmonary disease, Helicobacter pylori, infection

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