•  
  •  
 

Article Type

Original Study

Abstract

Objective

The aim of this study is to compare the effect of the short and long letrozole therapy for ovulation induction in clomiphene‑resistant women with polycystic ovary syndrome. Design

This was a prospective study. Patients and methods

Sixty infertile women were selected from the patients attending the outpatient clinic of Benha Teaching Hospital. All patients were diagnosed as having anovulation due to polycystic ovary syndrome. Intervention

Patients were randomly allocated to treatment with either long letrozole therapy (\[n=30;\] three cycles) or short letrozole therapy (\[n=30;\] three cycles). Main outcome measure

Number of growing, mature follicles and the occurrence of pregnancy. Results

The number of ovulating patients was greater in the long letrozole group (73.3 vs. 56.7%) but without statistical differences. The total number of follicles during stimulation was greater in the long letrozole group. The number of follicles more than or equal to 18 mm was significantly greater in the long letrozole group. Pregnancy occurred in four (13.3%) in the short group and seven (23.3%) in the long letrozole group, and the difference was statistically insignificant. Conclusion

The long letrozole protocol (10 days) can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy (5 days).

Keywords

Clomiphene resistance, extended letrozole, ovulation induction, polycystic ovary syndrome

Download

Share

COinS