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Article Type

Original Study

Abstract

Objective To investigate the level of vitamin D and the effect of its therapy on quality of life in patients with fibromyalgia who had vitamin D deficiency. Patients and methods Sixty patients presenting with fibromyalgia and 30 healthy controls were studied. Patients were grouped as deficient (<20 ng/ml), inadequate (20–30 ng/ml), and sufficient (>30 ng/ml) according to the levels of vitamin D. Vitamin D replacement was performed for patients with deficiencies and inadequacies and they were assessed before and after vitamin D therapy using the following scales: visual analog scale, fibromyalgia impact questionnaire, short form-36, Arizona sexual life questionnaire, and Beck depression scale and correlation were also calculated between vitamin D and different scores. Results Sixty women with fibromyalgia were included in this study. The mean age of all fibromyalgia patients was 30.9±6.1 years. Vitamin D deficiencies and inadequacies were observed in 63.3% of the patients (n=42). The 25(OH)D levels increased significantly after 3 months of supplementation. In scales examined after vitamin D replacement therapy, statistically significant differences were observed in the fibromyalgia impact questionnaire, Beck depression inventory, visual analog scale, and short form-36 compared with pretreatment; also there is negative correlation between vitamin D levels and parameters of measuring quality of life. Conclusion Vitamin D deficiency may be associated with fibromyalgia. Vitamin D supplementation seems to improve symptoms and quality of life in patients with fibromyalgia.

Keywords

Depression, fibromyalgia, quality of life, vitamin D, widespread pain

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