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Article Type

Original Study

Abstract

Introduction Pomegranate peels (Punica granatum) (contain fiber and antioxidants, which are beneficial to our health. This study aimed to investigate the effects of different concentrations of pomegranate peels on blood glucose, lipid profiles, and some physiological parameters, such as liver and kidney functions, in rats having diabetes and hypercholesterolemia. Methods Rats were divided into three main groups: the first main group was the negative control, the second main group was diabetic rats, and the third main group was hypercholesterolemic rats. Second and third main groups were divided into four subgroups (six rats/group) and fed with different diet levels of pomegranate peels (5, 10, and 15%) for 28 days. Body weight gain, feed intake, feed efficiency ratio, and relative weight of some organs were calculated at the end of the experiment. Fasting blood sample was taken for determination of serum glucose, total cholesterol, triglycerides, creatinine, urea, aspartate aminotransferase, and alanine aminotransferase. Results There was a significant reduction in both serum total cholesterol and triglycerides in all treated groups with pomegranate peels. The higher peels doses improved liver and kidney functions. However, the highest reduction was achieved by feeding diabetic rats with 15% pomegranate peels. Conclusion The study concluded that pomegranate peels ameliorated blood glucose, lipid profiles, liver enzymes, and kidney functions.

Keywords

Blood glucose, kidney function, lipid profile, liver, pomegranate peel

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