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Article Type

Original Study

Abstract

Background Degradation of the extracellular matrix is a basic step in the formation of endometriosis. The extracellular matrix degradation operated by matrix metalloproteinases (MMPs) Because matrix metalloproteinases (MMPs) are essential in orchestrating proper physiological functioning of the endometrium. MMP-9 is affected by many factors such as prostaglandin E2, tumor necrosis factor-α, interleukin 1β, interferon-γ, and tissue inhibitors of matrix metalloproteinase. Objective The aim of the present study was to evaluate MMP-9 forms in the ectopic and eutopic endometrial tissue of women with endometriosis. Patients and methods The study was carried upon 56 patients. Patients were divided into two groups (study and control). The study group included 28 patients, which were infertile, and in whome diagnostic laparoscopy, open laparotomy or hysterectomy for non-malignant lesions (fibroids) showed endometriotic implants. Control group included the other 28 patients, which were normal and fertile. Specimens were prepared and MMPs-9 was immunohistochemically detected and assessed in tissue sections. Results The results of the current study showed a significant increase in MMP-9 expression in the ectopic endometrial tissue of women with endometriosis. Conclusion MMP-9 could be considered a good marker for endometriosis and might play a significant role in the progression of endometriosis.

Keywords

Ectopic endometrial tissue, endometriosis, matrix metalloproteinase-9

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