Abstract
Background Joint affection is the most common extraintestinal manifestation of ulcerative colitis (UC). Despite the high specificity of anti-cyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in UC remains unclear. Aim The aims of this study were to assess the prevalence of anti-CCP antibodies in patients with UC and to investigate any association with joint affection. Patients and methods A total of 60 patients with UC were studied. Demographic data were collected, careful history was taken, and clinical examination including rheumatologic examination was done. A blood sample was collected for assessment of anti-CCP and other laboratory tests. Colonoscopy was done for assessment of severity and extension of UC. Results Joint affection was found in 28.33% of patients. Anti-CCP antibody was positive in 8.33% of patients. There were no statistically significant differences between patients with positive and negative anti-CCP antibody regarding joint affection or UC activity or extension. Conclusion The prevalence of anti-CCP antibodies in patients with UC was 8.33%, but there was no association between the presence of these antibodies and the joint affection or disease activity or extension.
Article Type
Original Study
Recommended Citation
El-Shimy, Aisha; Shabaan, El Saied E.; Mohamed, Hala I.; Safy, Mohamed A.; Fouad, Tarek A.; and Gomah, Wael
(2018)
"Anti-cyclic citrullinated peptide antibodies in ulcerative colitis with and without joint involvement,"
Journal of Medicine in Scientific Research: Vol. 1:
Iss.
4, Article 4.
DOI: https://doi.org/10.4103/JMISR.JMISR_82_18
