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Article Type

Original Study

Abstract

Background In the last few years, metabolic syndrome (MS) has gained much attention. The definition of the MS was established in 2005. Some studies have shown that there is an association between MS and inflammation, proven by high-sensitivity C-reactive protein (hs-CRP), but in limited population-based studies. This study tried to show the association between MS and us-CRP in the general population. Patients and methods A total of 200 persons were included in this cross-sectional study. The guidelines from the National Heart, Lung, and Blood Institute and the American Heart Association were used in the diagnosis of MS. Any three of the following traits in the same individual meet the criteria for the MS: (a) abdominal obesity: a waist circumference of 102 cm or more in men and 88 cm or more in women, (b) serum triglycerides of 150 mg/dl or above, (c) high-density lipoprotein cholesterol of 40 mg/dl or lower in men and 50 mg/dl or lower in women. (d) Blood pressure of 130/85 or more, (e) fasting blood glucose of 100 mg/or more. Commercial kits were used to determine the level of CRP. Results Individuals with MS had a higher mean us-CRP value in global measures (P < 0.001) and were stratified by sex (P < 0.001) than individuals without the syndrome. This marker showed a significant difference with different criteria for MS, such as the circumference of waist (P < 0.001), triglycerides levels (P < 0.001), and diastolic blood pressure (P < 0.001), and the highest levels of us-CRP were found in individuals with more MS criteria. Conclusion Us-CRP was highly associated with the presence of MS and MS criteria. Us-CRP is a good marker for showing the development of MS and may be used as a reference in routine care.

Keywords

C-reactive protein, cardiovascular risk factors, metabolic syndrome

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