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Article Type

Original Study

Abstract

Introduction Diabetic nephropathy has been identified as an essential risk factor for foot ulceration and amputation. Renal failure has been reported to independently predict the risk of nonhealing ischemic and neuroischemic foot lesions and major amputation. Objective In this study, we aimed at assessing the renal function of diabetic foot infected patients. Patients and methods We included 120 patients with type 2 diabetes mellitus, patients participated from the medical and surgical unit, Shebin El Kom Teaching Hospital, Egypt. They were divided into two main group; group 1 included 80 patients with an active diabetic foot ulcer (DFU) and group 2 included 40 patients without an active or past history of DFU. Also, group 1was subdivided into two groups; 40 patients were included in group A, who had antibiotic therapy with a low profile of renal toxicity (ceftriaxone, clindamycin, and ciprofloxacin) and 40 patients were included in group B who had antibiotic therapy with a high profile of renal toxicity (imipenem, aminoglycosides, and vancomycin). Result Patients with DFU had significant increase in neuropathy, history of lower limb amputation, and cerebrovascular accident. Also, patients with DFU had increased fasting blood glucose, 2 h postprandial glucose, glycated hemoglobin. Moreover, patients with DFU had increased serum creatinine and decreased estimated glomerular filtration rate. Also, serum creatinine was high in patients with DFU who received antibiotics with higher nephrotoxicity. Conclusion There was a strong association between the degree of renal impairment and DFU. Renal function decreased after antibiotherapy. In patients receiving antibiotics with higher nephrotoxicity, its decline was steeper. Further study is required to identify factors affecting renal function in patients with a DFU.

Keywords

Amputation, diabetic foot, renal function

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