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Abstract

Background: Central corneal thickness (CCT) is crucial in ophthalmic practice helping diagnosis and management of various conditions such as glaucoma, keratoconus, corneal dystrophy, contact lens use and proceeding refractive procedures assessment. A lot of non-contact modalities are currently available for CCT evaluation including anterior segment optical coherence tomography (AS-OCT) and the Pentacam systems so we are in need of determining the degree of agreement between these instruments to establish an accurate clinical interpretation. Aim: To test correlation between corneal thickness measurements obtained using Pentacam and AS-OCT. Patients and Methods: Our comparative observational study included 50 eyes. CCT was measured in each eye using both Pentacam and AS-OCT. Paired t-tests were applied to assess differences between measurements of both machines, while Pearson correlation analysis evaluated the relationship between them and Bland–Altman analysis was used to determine agreements. Results: The mean CCT measured by AS-OCT was greater than that measured by Pentacam (501.3 ± 32.6 μm versus 492.0 ± 31.8 μm p < 0.001). Very strong positive correlation was noticed among the two techniques (r = 0.99, p < 0.001). Bland–Altman analysis demonstrated a mean measurement bias 9.28 μm( with 95% limits of agreement ranging from -5.45 to 24.01 μm). Conclusion: AS-OCT and Pentacam measurements of CCt showed an excellent correlation but AS-OCT consistently yields higher values. Given the observed systematic bias and wide limits of agreement, we should not use the two devices interchangeably in our routine clinical practice.

Article Type

Original Study

Subject Area

Ophthalmology

IRB Number

HM000187

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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