Physiological, Cytogenetic, and Nutrition Effects of Garcinia cambogia and Ginkgo biloba aqueous extracts on the reproductive functions of diabetic male rats

Authors

• Marwa E. Hassan, Pesticide department, Research Institute of Medical Entomology, (GOTHI), Giza, Egypt.Follow
• Mahmoud M. Ahmed, Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt
• Sherien A. Montaser, Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
• Sherein S. Abdelgayed, College of Veterinary Medicine, Tuskegee University, AL36088, USA
• Asmaa M.I. El Gamal, Assistant professor of Nutrition and Food Science, Ahmed Maher Teaching Hospital, (GOTHI), Giza, Egypt.

Abstract

Introduction

Diabetes disturbed humans from living normally, while Nature tries to help us again. Remarkable herbs biodiversity reflects a wide array of mechanisms.

Aim

Present study aims to track male annoying consequences of diabetic on fertility, trying to improve these hazards using two different herbs Garcinia cambogia and Ginkgo biloba.

Materials and methods

30 male Albino Sprague Dawely rats in six groups (5 rats each). Groups; 1^st group (negative control). 2^nd and 3^rd were treated orally with (200 mg/kg bw) for both G. cambogia and G. biloba. 4^th was +ve control (diabetic rat model) induced by alloxan injection (150 mg/kg bw) once. 5^th and 6^th were treated after diabetes induction with two herbs. Treatment period was 1 month after diabetes induction.

Results

Obtained data revealed diabetic group treated with G. biloba recorded reduction in sperm morphology abnormalities, lowering serum Triglycerides and low density lipoprotein (LDL) concentration caused as terrible effects of diabetes. More amazing data showed in diabetic rat group treated with G. cambogia recorded significant amelioration in all sex hormones levels such as (prolactin, follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterone. and verify fixation to its level after drastic effect of diabetes.

Conclusion

Garcinia cambogia and Ginkgo biloba demonstrate promising protective effects against diabetes-induced reproductive dysfunction, suggesting their potential as complementary therapeutic agents for improving male fertility under diabetic conditions.

Article Type

Original Study

Subject Area

Clinical and Chemical Pathology

IRB Number

IME00082

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Recommended Citation

Hassan, Marwa E.; Ahmed, Mahmoud M.; Montaser, Sherien A.; Abdelgayed, Sherein S.; and El Gamal, Asmaa M.I. (2026) "Physiological, Cytogenetic, and Nutrition Effects of Garcinia cambogia and Ginkgo biloba aqueous extracts on the reproductive functions of diabetic male rats," Journal of Medicine in Scientific Research: Vol. 9: Iss. 4, Article 16.
DOI: https://doi.org/10.59299/2537-0928.1552