Role of Complete Blood Cells indices in Predicting Neonatal Sepsis Mortality

Authors

• Sohaila Ali Abd El-Halim, Department of Pediatrics & Neonatology , Mataria Teaching Hospital, General Organization for Teaching Hospitals and Institutes Cairo, EgyptFollow
• Marwa Taha, Department of Pediatrics & Neonatology , Mataria Teaching Hospital, General Organization for Teaching Hospitals and Institutes Cairo, Egypt
• Fifi Helmy Aboualy, Department of Pediatrics & Neonatology , Mataria Teaching Hospital, General Organization for Teaching Hospitals and Institutes Cairo, Egypt
• Raghda Samir Abdellatif, Department of Clinical Pathology –National Hepatology and Tropical Medicine Research Institute. , General Organization for Teaching Hospitals and Institutes Cairo, Egypt
• Mai Mohammed Mostafa, Department of Pediatrics & Neonatology , Mataria Teaching Hospital, General Organization for Teaching Hospitals and Institutes Cairo, Egypt

Abstract

Background: Neonatal sepsis remains a leading cause of morbidity and mortality in newborns. Identifying reliable prognostic markers is crucial for early diagnosis and treatment. Elevated levels of C-reactive protein (CRP) and increased platelet distribution width (PDW) have been associated with adverse outcomes in septic neonates. Objective: This study was performed in an attempt to assess the predictive value of Complete Blood Count (CBC) indices, including red cell distribution width (RDW), mean platelet volume (MPV), and PDW for mortality in septic neonates. Patients and Methods: This cohort study was conducted in the neonatal intensive care unit (NICU) of Mataria Teaching Hospital (MTH) on 135 neonates diagnosed with sepsis, over one-year period, from December 2022 to November 2023. CBC indices were assessed and recorded at the time of clinical sepsis diagnosis among all patients. Based on outcomes, the neonates were categorized into survivor and non-survivor groups. Results: The cohort comprised 70 females and 65 males, with survival rates of 78.6% and 70.8%, respectively. Mode of delivery and parity did not significantly affect outcomes. Notably, higher CRP levels were associated with increased mortality: 35.3% of non-survivors had CRP levels of 96 mg/L, compared to 14.9% of survivors. Additionally, non-survivors had a significantly higher mean PDW (15.2 fl) than survivors (10.7 fl), with a p-value of 0.001. Conclusion: Elevated CRP levels and increased PDW are associated with higher mortality in neonates diagnosed with sepsis. These findings suggest that both CRP and PDW can serve as valuable prognostic markers in assessing severity and potential outcomes of neonatal sepsis.

Article Type

Original Study

Subject Area

Pediatrics

IRB Number

HM000143

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Recommended Citation

El-Halim, Sohaila Ali Abd; Taha, Marwa; Aboualy, Fifi Helmy; Abdellatif, Raghda Samir; and Mostafa, Mai Mohammed (2026) "Role of Complete Blood Cells indices in Predicting Neonatal Sepsis Mortality," Journal of Medicine in Scientific Research: Vol. 9: Iss. 4, Article 13.
DOI: https://doi.org/10.59299/2537-0928.1511