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Abstract

Background:

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia and associated complications. Red cell distribution width (RDW), an index of the variability in red blood cell size, has emerged as a potential biomarker of inflammation and vascular risk.

Objective:

To assess the association between RDW and T2DM and its relation to glycemic control

Patients and Methods:

The current case-control study enrolled 40 T2DM patients and 20 age- and sex-matched healthy controls. Data collected included fasting blood sugar (FBS), 2-hour postprandial glucose (2hPP), HbA1c, lipid profile, albumin/creatinine ratio (ACR), and RDW. Statistical analysis included t-tests, Pearson correlations, and logistic regression

Results:

RDW was statistically significant in T2DM patients as opposed to controls (16.3 ± 1.2 vs 13.0 ± 0.3, p < 0.001). RDW correlated strongly with HbA1c, FBS, 2hPP, and ACR (r = 0.75, 0.71, 0.69, and 0.68, respectively, all p < 0.001).

Conclusion

RDW is increased in T2DM and strongly correlates with glycemic and renal parameters, suggesting its potential as a simple, inexpensive biomarker of disease severity.

Article Type

Original Study

Subject Area

Internal Medicine

IRB Number

HM000150

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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