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Abstract

Background: The optimal anesthetic approach for the care of pediatric patients facing cardiac catheterization stays undefined. Therefore, this study sought to equivalence the impact of ketamine-propofol and ketamine-dexmedetomidine mixtures on recovery duration and hemodynamic parameters in pediatric patients suffering trivial procedures and cardiac catheterization, while sedated for the treatment of numerous congenital heart diseases.

Materials and Method: One hundred twenty-six pediatric patients, irrespective of sex, scheduled for cardiac catheterization were arbitrarily billed to one of two groups: a propofol-ketamine group (PK) and a dexmedetomidine-ketamine group (DK), every comprising sixty-three patients. Group (DK) established Dexmedetomidine iv infusion 1µg/kg over ten min + ketamine1mg/kg bolus, obeyed by iv infusion of Detox (1:1) in a does 1mcg/kg/hr. Dex. or 1mg/kg/hr. Ketamine. Group (PK) gotten an IV loading does of Ketofol (1:1)1mg/kg, then 0.1mg/kg/kg/hr. IVI for maintenance. Further doses of ketamine 0.5 mg/kg IV bolus were managed when a child confirmed tenderness in either groups with recovery time and Postoperative hemodynamic parameters were noted.

Results: No significant baseline alterations among the DK and PK groups. Intraoperatively, heart rate (HR) was significantly decreased the DK group at five, ten, fifteen, and twenty minutes after infusion initiation, while SpO₂, respiratory rate, and MAP remained comparable between groups, showing only small time-dependent declines within normal limits. Postoperatively, HR and SpO₂ values did not vary significantly among groups at any time point, although the DK group showed a greater time-related increase in HR. Recovery scores improved over time in both groups, but were decreased the DK group at baseline and 20 minutes, indicating slower emergence. Adverse events were more frequent with DK, particularly bradycardia and desaturation, whereas recovery time was significantly lesser and overall postoperative stability was increased in the PK group.

Conclusion: The dexmedetomidine-ketamine mixture provides a safe alternative, exhibiting no significant respiratory or hemodynamic alterations throughout cardiac catheterization; however, delayed recovery may occur

Article Type

Original Study

Subject Area

Anaesthesiology

IRB Number

IHC00099

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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