The RAGE gene crucial function in the etiology and consequences of Type I diabetes

Amal A. Mohamed, biochemistry and Molecular Biology Department, National Hepatology and Tropical Medicine Research Institute, GOTHI, Cairo, EgyptFollow
Mohamed O. Mahmoud, Department of Biochemistry, Faculty of Pharmacy, Beni suef University, Beni Suef, Egypt
Gamil M. Abdallah, Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt
Nada S. Ali, Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt
Mona AbdelMotaleb Abdelfatah Hussein, Internal medicine department, National Institute of Diabetes and Endocrinology, GOTHI, Cairo, Egypt.
Ibrahim T. Ibrahim, Department of Biochemistry, Faculty of Pharmacy, Beni suef University, Beni Suef, Egypt

Article Type

Review

Subject Area

Endocrinology

Abstract

Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It is an auto-immune illness brought on by an association of environmental and genetic variables. that cause T lymphocytes to destroy insulin-producing β-cells. Its prevalence continues to rise by 3-4% annually worldwide, enhancing the risk of mortality. So, the idea of diabetic kidney disease (DKD) is widely established, and systemic treatment is essential. RAGEs are linked to inflammatory disorders that exist in a variety of TID-related cells; especially T cells. Variations in circulating RAGE concentrations have been linked to a higher chance of developing TID. Furthermore, T cells from at-risk individuals who develop TID have higher RAGE expression, which promotes T-cell cytokine generation. AGEs seemed to be the earliest RAGE ligands discovered, and they may suppressed by nutritional and medical interventions. Pre-diabetes had a higher concentration of AGE, which is a good predictor of TID. It remains increased following TID diagnosis, and it is hypothesized that they are linked to the development and advancement of long-lasting problems including retinopathy, nephropathy, and coronary heart disease. This review will provide a summary of RAGE’s gene structure, describe the biological and pathophysiological activities, and give insight into how it contributes to the start, progression, and management of TID.

IRB Number

IDE00296

Keywords

TID, RAGE, AGEs, auto-immune disorders

Recommended Citation

Mohamed, Amal A.; Mahmoud, Mohamed O.; Abdallah, Gamil M.; Ali, Nada S.; Hussein, Mona AbdelMotaleb Abdelfatah; and Ibrahim, Ibrahim T. (2024) "The RAGE gene crucial function in the etiology and consequences of Type I diabetes," Journal of Medicine in Scientific Research: Vol. 7: Iss. 2, Article 7.
DOI: https://doi.org/10.59299/2537-0928.1069