Clinical findings and hematological parameters in cases of acute lymphoblastic leukemia with thrombocytosis at initial diagnosis

Anurag Singh, Departments of Pathology King George Medical University, Lucknow, Uttar Pradesh, India
Sanjay Mishra, Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh 226003, IndiaFollow
Tanya Tripathi, Departments of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
Akanksha Singh, Departments of Pathology , King George Medical University, Lucknow, Uttar Pradesh, India
Rashmi Kushwaha, Departments of Pathology , King George Medical University, Lucknow, Uttar Pradesh, India
S.P. Verma, Department of Clinical Hematology, King George Medical University, Lucknow, Uttar Pradesh, India
U.S. Singh, Departments of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India

Article Type

Original Study

Subject Area

Pathology

Abstract

Background Acute lymphoblastic leukemia (ALL) is a bone marrow and blood neoplasm involving precursor cells, or lymphoblasts, dedicated to B/T-cell lineages. ALL usually presents with bicytopenia/pancytopenia and thrombocytopenia is the most important key parameter. Thrombocytosis has not been a well-described feature of ALL; hence, this study was planned to investigate the incidence of thrombocytosis at initial diagnosis and its correlation with clinicohematological parameters, immunophenotyping, and cytogenetic study. Aim The aim was to investigate the incidence of thrombocytosis in newly diagnosed cases of ALL and its correlation with clinicohematological parameters, immunophenotyping, and cytogenetics. Materials and methods Medical records of all patients diagnosed as ALL at the King George’s Medical University Lucknow Leukemia-Lymphoma lab over a 5-year period were retrieved. The primary focus of this study was on individuals who had thrombocytosis at initial diagnosis. These patients’ records were retrieved for chief clinical complaints, laboratory data, immunophenotyping, and cytogenetics. Results We retrieved a total of 167 immunophenotypically confirmed cases of ALL at the leukemia-lymphoma lab of King George’s Medical University, Lucknow over a 5-year period to see how frequently thrombocytosis is associated with ALL and whether there are other associated clinical, laboratory, and cytogenetics findings. Out of 167 cases, six (3.5%) had thrombocytosis at initial diagnosis. No clinical findings among the selected patients clearly showed an association with thrombocytosis, including total leukocyte count, hemoglobin, lymphoblast percentage, and immunophenotypic and karyotyping. None of the patients had major induction-related complications. Conclusion To summarize, thrombocytosis can be observed in ALL patients at initial diagnosis, particularly men. This group of patients had no risk of significant events during induction therapy, based on a smaller number of cases

Keywords

acute lymphoblastic leukemia, bicytopenia, flow cytometry, pancytopenia, thrombocytosis

Recommended Citation

Singh, Anurag; Mishra, Sanjay; Tripathi, Tanya; Singh, Akanksha; Kushwaha, Rashmi; Verma, S.P.; and Singh, U.S. (2023) "Clinical findings and hematological parameters in cases of acute lymphoblastic leukemia with thrombocytosis at initial diagnosis," Journal of Medicine in Scientific Research: Vol. 6: Iss. 1, Article 4.
DOI: https://doi.org/10.59299/2537-0928.1021